Histoire et Innovation

A biotechnological breakthrough that redefines modern cosmetology.

1-LGVTY^®

Our patented 1-LGVTY® technology rejuvenates the biological age of the skin by targeting the three cellular stresses responsible for skin aging: inflammatory, oxidative, and microbiological stress.

Comparison of skin explants from the clinical study

Stress situation vs. 1-LGVTY + stress situation

1 Significant reduction in inflammation

Inflammatory stresses, whether acute or chronic, impact skin longevity. This inflammation, often referred to as inflammaging, alters cellular functions, disrupts the skin barrier, and accelerates the decline of the skin’s biological performance. In our models using UV-exposed explants, the patented 1-LGVTY^® technology significantly reduces the cytokines IL-1α and IL-6, two key biomarkers of inflammatory responses involved in the progressive degradation of skin functions.

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Stress

Stress + 1-LGVTY^®

2 Net reduction in oxidation

Cutaneous oxidative stresses correspond to an imbalance between the production of reactive oxygen species (ROS). Regulating oxidative stress plays a key role in the potential for skin longevity. When ROS exceed natural antioxidant capacities, they alter lipids, structural proteins, and fibers, compromising the biological performance of the skin. In a model of explants subjected to acute oxidative stress, 1-LGVTY^® significantly reduces ROS production in keratinocytes, fibroblasts, and the extracellular matrix. By decreasing protein oxidation by 237%, the technology restores the skin’s ability to resist, recover, and preserve its longevity potential.

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Stress

Stress + 1-LGVTY^®

3 Microbiome rebalancing

Imbalances in the skin microbiome constitute real microbial stresses, influencing skin longevity. They disrupt skin homeostasis and weaken its natural defense mechanisms. In explants subjected to environmental stress (UV and pollution), 1-LGVTY^® stimulates the expression of antimicrobial peptides, particularly β-defensins-2, as well as that of immunomodulatory mediators, which contribute to maintaining a functionally stable microbiome essential for promoting skin longevity.

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Stress

Stress + 1-LGVTY^®

The actions of 1-LGVTY on biomarkers of skin longevity:

1 Decrease in melanin

The regulation of melanogenesis is essential for skin longevity, as excessive or imbalanced melanin production indicates a disruption of the skin’s protective mechanisms. In an explant model subjected to pigmentary stress (UV/inflammation), 1-LGVTY^® reduces melanin levels by 80% and decreases tyrosinase activity by 125%, improving pigmentation and skin longevity while evening out the complexion.

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Stress

Stress + 1-LGVTY^®

2 Increase in collagen synthesis

The quality of the collagen network is one of the most determining indicators of skin longevity. Over time, its synthesis decreases while its degradation accelerates, leading to loss of density, firmness, and the appearance of wrinkles. In a model of explants subjected to combined UV + pollution stress, 1-LGVTY^® preserves type I collagen fibers and stimulates their production by 114%, enhancing the structural longevity of the dermis and the stability of its extracellular matrix.

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Stress

Stress + 1-LGVTY^®

3 Increase in hyaluronic acid synthesis

Hyaluronic acid, through its interaction with the CD44 receptor, modulates key longevity processes such as hydration, skin repair, and cell signaling. It ensures cellular cohesion, deep hydration, and the skin’s ability to regenerate. In a model of explants subjected to UV and pollution, tissues treated with 1-LGVTY^® show a 98% stimulation of CD44 receptor expression, revealing better preservation of endogenous hyaluronic acid, enhanced cellular cohesion, and strengthening of the skin barrier essential for skin longevity.

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